RAD21L1

Across TCGA patient cohorts, RAD21L1 mutation is significantly associated with the RNA expression of many other genes, with 3,000 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD21L1-associated genes across cancer lineages are MIR3159, RNY1P1, and RNU6-1064P. Each is linked with RAD21L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD21L1-to-partner and partner-to-RAD21L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3159 grouped by RAD21L1-low versus RAD21L1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD21L1→partner) and Y-score (partner→RAD21L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR3159 →	+0.481	+5.683	<.001	.004	3	2
UCEC	RNY1P1 →	+0.148	+2.876	<.001	.002	3	2
UCEC	RNU6-1064P →	+0.392	+1.516	.003	.007	3	2
UCEC	RNU6-1213P →	+0.177	+3.417	<.001	<.001	3	2
BRCA	OR7E149P →	+0.045	+5.148	<.001	.008	3	1
BRCA	RNU6-1059P →	+0.171	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,000 associations by consensus.

MIR3159 by RAD21L1 expression — BRCA

Explore this box plot interactively →