RAD21L1

Across TCGA pan-cancer cohorts, RAD21L1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RAD21L1 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RAD21L1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAD21L1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

KIRC, CESC, and LUAD are the cancer types where RAD21L1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.528	0.726	<.001	108	view →
CESC	OS	Median	All	0.816	0.908	<.001	60	view →
LUAD	OS	Quartile	All	0.256	0.402	.001	45	view →
SKCM	OS	Median	II,III,IV	0.925	0.775	.001	43	view →
SCLC	OS	Quartile	All	0.508	0.164	.010	30	view →
ACC	OS	Median	All	0.694	0.885	.004	24	view →
COAD	DFS	Tertile	II,III,IV	0.301	0.566	.010	22	view →
HNSC	OS	Quartile	All	0.673	0.767	.002	20	view →
UCEC	DFS	Tertile	All	0.567	0.667	.024	18	view →
PAAD	DFS	Quartile	All	0.679	0.418	.011	17	view →
READ	OS	Tertile	III,IV	0.842	0.312	.017	14	view →
PCPG	OS	Quartile	All	0.823	1.000	.003	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

RAD21L1–KIRC (DFS)

Open the KIRC breakdown →