RAD21L1

Across TCGA patient cohorts, RAD21L1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD21L1-associated genes across cancer lineages are ASNS, 14-3-3_beta, and eEF2. Each is linked with RAD21L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD21L1-to-partner and partner-to-RAD21L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RAD21L1-low versus RAD21L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD21L1→partner) and Y-score (partner→RAD21L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.449	+2.584	.001	.010	3	2
UCEC	14-3-3_beta →	-0.113	-2.401	.005	.003	3	1
UCEC	eEF2 →	+0.495	+3.321	<.001	.009	3	1
UCEC	A-Raf_pS299 →	-0.195	-3.700	<.001	.001	3	1
UCEC	GAPDH →	+0.565	+2.415	.008	.003	3	1
UCEC	GATA6 →	-0.202	-2.314	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ASNS by RAD21L1 expression — UCEC

Explore this box plot interactively →