RAD21L1

Across TCGA cell cohorts, RAD21L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,310 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RAD21L1-associated GO terms across cancer lineages are Positive regulation of protein K48-linked ubiquitination, Positive regulation of focal adhesion assembly, and Cardiac muscle cell action potential. Each is linked with RAD21L1 in more than 6 cancer types. Because this analysis shows association rather than direction, both RAD21L1-to-partner and partner-to-RAD21L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein K48-linked ubiquitination grouped by RAD21L1-low versus RAD21L1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD21L1→partner) and Y-score (partner→RAD21L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of protein K48-linked ubiquitination →	+0.096	+0.270	<.001	<.001	3	7
OVARY	Positive regulation of focal adhesion assembly →	+0.125	+0.460	<.001	<.001	3	6
LARGE_INTESTINE	Cardiac muscle cell action potential →	-0.110	-0.075	<.001	.009	3	5
PANCREAS	Regulation of muscle cell differentiation →	+0.040	+0.100	<.001	.004	3	5
CNS	Regulation of epidermal growth factor receptor signaling pathway →	+0.035	+0.193	<.001	<.001	3	5
OVARY	Replication-born double-strand break repair via sister chromatid exchange →	-0.156	-0.487	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,310 associations by consensus.

Positive regulation of protein K48-linked ubiquitination by RAD21L1 expression — CNS

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