RAD21L1

Across TCGA cell cohorts, RAD21L1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RAD21L1-associated genes across cancer lineages are IL3, PRAMEF10, and PRAMEF17. Each is linked with RAD21L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD21L1-to-partner and partner-to-RAD21L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by RAD21L1-low versus RAD21L1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD21L1→partner) and Y-score (partner→RAD21L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	1
SKIN	PF4 →	+0.478	+3.758	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

IL3 by RAD21L1 expression — LUNG_SCLC

Explore this box plot interactively →