RAD21-AS1

Across TCGA pan-cancer cohorts, RAD21-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RAD21-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RAD21-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types RAD21-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and KICH are the cancer types where RAD21-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAD21-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.485	<.001	9	view →
HNSC	All	III,IV	+0.184	.004	7	view →
KICH	Female	II,III,IV	−0.618	<.001	6	view →
LIHC	Male	All	+0.231	<.001	6	view →
KIRP	All	All	−0.285	<.001	5	view →
BRCA	All	All	+0.212	.003	4	view →
CHOL	All	All	+0.273	.010	2	view →
PRAD	All	All	+0.136	.021	2	view →
BLCA	Male	III,IV	−0.395	.047	1	view →
LUSC	All	All	+0.158	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RAD21-AS1–THCA

Open the THCA breakdown →