RAD18

Across TCGA cell cohorts, RAD18 mutation is significantly associated with the mutation status of many other genes, with 3,899 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAD18-associated genes across cancer lineages are PDK4, WIPI1, and ELOA. Each is linked with RAD18 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAD18-to-partner and partner-to-RAD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK4 grouped by RAD18-low versus RAD18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD18→partner) and Y-score (partner→RAD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PDK4 →	+5.560	+4.736	.003	.003	1	3
LARGE_INTESTINE	WIPI1 →	+4.392	+3.087	.005	.005	1	3
BLOOD_Leukemia	ELOA →	+5.145	+5.145	<.001	<.001	1	3
BLOOD_Leukemia	TCFL5 →	+4.145	+4.635	.001	.001	1	3
BLOOD_Leukemia	PPFIBP1 →	+3.145	+3.932	.004	.004	1	3
BLOOD_Leukemia	CUX2 →	+2.975	+3.794	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,899 associations by consensus.

PDK4 by RAD18 expression — BLOOD_Leukemia

Explore this box plot interactively →