Across TCGA pan-cancer cohorts, RACK1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RACK1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RACK1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated RACK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, PRAD, and LIHC are the cancer types where RACK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.626	.012	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LIHC	OS	Median	All	0.031	0.775	<.001	6	view →
SKCM	DFS	Median	All	0.945	0.613	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RACK1 tumor-vs-normal RNA expression · all RACK1 data types