Across TCGA pan-cancer cohorts, RACK1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RACK1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RACK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RACK1 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.
KIRC, COAD, and KIRP are the cancer types where RACK1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RACK1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.