Across TCGA pan-cancer cohorts, RACK1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RACK1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RACK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RACK1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where RACK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.641	0.916	<.001	48	view →
LUAD	DFS	Median	All	0.969	0.840	.005	21	view →
GBM	DFS	Quartile	All	0.235	0.517	.006	5	view →
HNSC	DFS	Median	III,IV	0.769	0.514	.012	5	view →
PDAC	DFS	Tertile	III,IV	0.257	0.524	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RACK1 tumor-vs-normal RNA expression · all RACK1 data types