Across TCGA patient cohorts, RACK1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RACK1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FoxM1. Each is linked with RACK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RACK1-to-partner and partner-to-RACK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RACK1→partner) and Y-score (partner→RACK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.244	-1.807	.018	.027	3	1
UCEC	eIF4E →	+0.251	+3.335	.003	.005	3	1
UCEC	FoxM1 →	+0.279	+3.179	.009	.010	3	1
UCEC	FOXO3a →	+0.090	+1.750	.031	.049	3	1
UCEC	MEK1 →	+0.534	+3.000	<.001	.001	3	1
UCEC	Notch1 →	+0.218	+2.594	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

RACK1 survival (RNA) · tumor vs normal (RNA) · all RACK1 data types