RAC3

Across TCGA pan-cancer cohorts, RAC3 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RAC3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where RAC3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAC3 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where RAC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−0.613	<.001	7	view →
PDAC	All	All	+0.696	<.001	4	view →
LSCC	All	All	+0.154	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

RAC3–CCRCC

Open the CCRCC breakdown →