RAC3

Across TCGA pan-cancer cohorts, RAC3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RAC3 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RAC3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAC3 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRP show a favorable association.

KIRC, ACC, and BLCA are the cancer types where RAC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.556	0.688	<.001	162	view →
ACC	DFS	Median	All	0.333	0.818	<.001	146	view →
BLCA	DFS	Median	All	0.426	0.593	<.001	133	view →
MESO	OS	Median	All	0.393	0.686	<.001	82	view →
SKCM	OS	Tertile	All	0.272	0.399	<.001	62	view →
UCEC	DFS	Median	All	0.771	0.902	<.001	50	view →
SARC	DFS	Tertile	All	0.393	0.630	<.001	46	view →
LGG	OS	Median	All	0.519	0.364	<.001	43	view →
UVM	OS	Quartile	II,III,IV	0.460	0.903	.009	34	view →
KIRP	DFS	Median	III,IV	0.801	0.154	.004	34	view →
LIHC	DFS	Median	All	0.204	0.353	.002	33	view →
THCA	OS	Tertile	All	0.854	0.965	.012	33	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RAC3–KIRC (DFS)

Open the KIRC breakdown →