RAC3

Across TCGA cell cohorts, RAC3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAC3-associated genes across cancer lineages are MAGEB4, STRA8, and ZNF804B. Each is linked with RAC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAC3-to-partner and partner-to-RAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by RAC3-low versus RAC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAC3→partner) and Y-score (partner→RAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ZNF804B →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.336	+5.415	<.001	.004	3	1
BLOOD_Leukemia	TSHB →	+0.119	+4.691	.002	<.001	3	1
BLOOD_Leukemia	C16orf92 →	+0.167	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MAGEB4 by RAC3 expression — LARGE_INTESTINE

Explore this box plot interactively →