RAC1

Across TCGA pan-cancer cohorts, RAC1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RAC1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RAC1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAC1 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, CCRCC, and HNSC are the cancer types where RAC1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAC1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.488	<.001	9	view →
CCRCC	Male	All	+0.223	<.001	9	view →
HNSC	All	All	−0.334	<.001	7	view →
LSCC	All	II,III,IV	−0.181	<.001	7	view →
PDAC	Male	All	+0.761	<.001	5	view →
LUAD	Female	III,IV	+0.165	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RAC1–COAD

Open the COAD breakdown →