RAC1

Across TCGA pan-cancer cohorts, RAC1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RAC1 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher RAC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RAC1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and ESCA show a favorable association.

MESO, ACC, and LIHC are the cancer types where RAC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.411	0.663	<.001	114	view →
ACC	DFS	Median	All	0.223	0.679	<.001	98	view →
LIHC	OS	Median	All	0.605	0.768	<.001	81	view →
LUAD	OS	Tertile	All	0.271	0.434	<.001	75	view →
PAAD	DFS	Tertile	All	0.218	0.479	<.001	58	view →
UCS	DFS	Tertile	III,IV	0.120	0.578	.002	36	view →
HNSC	OS	Quartile	II,III,IV	0.319	0.488	.009	36	view →
LGG	OS	Median	All	0.757	0.866	<.001	34	view →
DLBC	DFS	Tertile	All	0.805	0.281	.001	33	view →
UCEC	DFS	Median	IV	0.215	0.646	.003	24	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	24	view →
BRCA	OS	Tertile	IV	0.421	1.000	.004	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RAC1–MESO (OS)

Open the MESO breakdown →