RAC1

Across TCGA patient cohorts, RAC1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,777 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible RAC1-associated genes across cancer lineages are CXCR1, FFAR2, and ADGRE3. Each is linked with RAC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both RAC1-to-partner and partner-to-RAC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAC1 versus CXCR1 in HNSC, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAC1→partner) and Y-score (partner→RAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CXCR1 →	-0.973	-0.323	<.001	<.001	3	7
COAD	FFAR2 →	-1.344	-0.790	<.001	<.001	3	6
UCEC	ADGRE3 →	-0.611	-0.322	<.001	<.001	3	6
PDAC	FCGR3B →	-1.358	-0.785	<.001	<.001	3	6
COAD	CXCL8 →	-1.714	-0.634	<.001	<.001	3	6
COAD	CEACAM3 →	-0.862	-0.860	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,777 associations by consensus.

RAC1 vs CXCR1 — HNSC

Explore this scatter interactively →