RAC1

Across TCGA patient cohorts, RAC1 mutation is significantly associated with the RNA expression of many other genes, with 3,363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAC1-associated genes across cancer lineages are RPSAP49, RNU4-49P, and MIR3116-1. Each is linked with RAC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAC1-to-partner and partner-to-RAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPSAP49 grouped by RAC1-low versus RAC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAC1→partner) and Y-score (partner→RAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPSAP49 →	+0.363	+2.338	.006	.003	3	3
CESC	RNU4-49P →	+0.394	+5.345	<.001	.001	3	2
CESC	MIR3116-1 →	+0.521	+4.503	<.001	.005	3	2
CESC	RNVU1-28 →	+0.684	+4.705	<.001	.003	3	2
UCEC	MICALL1 →	+0.491	+3.716	.001	<.001	3	2
UCEC	TOMM22 →	+0.495	+2.158	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,363 associations by consensus.

RPSAP49 by RAC1 expression — UCEC

Explore this box plot interactively →