RAC1

Across TCGA patient cohorts, RAC1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAC1-associated genes across cancer lineages are A-Raf_pS299, INPP4B, and Ku80. Each is linked with RAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAC1-to-partner and partner-to-RAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RAC1-low versus RAC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAC1→partner) and Y-score (partner→RAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	A-Raf_pS299 →	-0.135	-2.321	.034	.032	3	2
UCEC	INPP4B →	-0.370	-3.584	.004	.002	3	2
SKCM	Ku80 →	+0.348	+2.700	.004	.006	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.438	-3.584	.015	.002	3	2
UCEC	PCNA →	+0.213	+1.906	.014	.016	3	2
UCEC	TFRC →	+0.752	+3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

A-Raf_pS299 by RAC1 expression — SKCM

Explore this box plot interactively →