RABGGTB

Across TCGA patient cohorts, RABGGTB mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RABGGTB-associated genes across cancer lineages are MEK1, Notch1, and p62 Lck ligand. Each is linked with RABGGTB in more than 1 cancer types. Because this analysis shows association rather than direction, both RABGGTB-to-partner and partner-to-RABGGTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RABGGTB-low versus RABGGTB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RABGGTB→partner) and Y-score (partner→RABGGTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.449	+2.584	.003	.010	3	2
UCEC	Notch1 →	+0.192	+2.222	.001	.011	3	1
UCEC	p62 Lck ligand →	+0.342	+2.222	.013	.011	3	1
UCEC	Annexin-1 →	+0.651	+3.479	.003	.002	3	1
UCEC	Rictor_pT1135 →	-0.096	-1.700	.027	.044	3	1
UCEC	Tuberin →	+0.284	+1.700	.013	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by RABGGTB expression — UCEC

Explore this box plot interactively →