RAB9B

Across TCGA patient cohorts, RAB9B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB9B-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and VHL. Each is linked with RAB9B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB9B-to-partner and partner-to-RAB9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RAB9B-low versus RAB9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB9B→partner) and Y-score (partner→RAB9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.112	-3.446	.026	.005	3	2
UCEC	EGFR_pY1068 →	-0.248	-2.321	.049	.035	3	1
UCEC	VHL →	-1.063	-3.459	.001	.005	3	1
UCEC	Caspase-8 →	-0.279	-3.169	.027	.019	2	1
UCEC	p62 Lck ligand →	+0.493	+2.321	.002	.035	1	1
UCEC	Cyclin-B1 →	+0.787	+2.321	.005	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

14-3-3_beta by RAB9B expression — UCEC

Explore this box plot interactively →