RAB8B

Across TCGA patient cohorts, RAB8B mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB8B-associated genes across cancer lineages are FoxM1, ATM, and EGFR_pY1068. Each is linked with RAB8B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB8B-to-partner and partner-to-RAB8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RAB8B-low versus RAB8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB8B→partner) and Y-score (partner→RAB8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.292	+3.807	.012	<.001	3	2
UCEC	ATM →	-0.437	-2.000	.032	.032	3	2
UCEC	EGFR_pY1068 →	-0.264	-3.807	.019	<.001	3	1
UCEC	eIF4E →	+0.200	+2.000	.035	.032	2	2
UCEC	A-Raf_pS299 →	-0.129	-3.169	.016	.019	3	1
UCEC	INPP4B →	-0.331	-3.169	.023	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FoxM1 by RAB8B expression — UCEC

Explore this box plot interactively →