RAB8B

Across TCGA pan-cancer cohorts, RAB8B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RAB8B data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RAB8B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RAB8B expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, SKCM, and STAD are the cancer types where RAB8B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.880	0.712	<.001	63	view →
SKCM	OS	Tertile	All	0.360	0.245	.002	47	view →
STAD	OS	Median	III,IV	0.517	0.754	.009	29	view →
LGG	OS	Quartile	All	0.448	0.844	<.001	22	view →
LUSC	DFS	Quartile	II,III,IV	0.291	0.515	.006	19	view →
MESO	OS	Median	All	0.298	0.457	.028	18	view →
PRAD	DFS	Quartile	All	0.947	0.843	.004	18	view →
DLBC	DFS	Median	All	0.662	1.000	.030	12	view →
KICH	OS	Median	II,III,IV	0.631	0.959	.003	10	view →
LIHC	OS	Quartile	III,IV	0.341	0.792	.001	8	view →
PAAD	OS	Median	All	0.266	0.589	.015	7	view →
THYM	OS	Quartile	All	1.000	0.744	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RAB8B–KIRC (DFS)

Open the KIRC breakdown →