RAB6B

Across TCGA patient cohorts, RAB6B mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB6B-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and JNK2. Each is linked with RAB6B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB6B-to-partner and partner-to-RAB6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RAB6B-low versus RAB6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB6B→partner) and Y-score (partner→RAB6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.248	-2.169	.008	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.210	-2.321	<.001	.005	3	2
UCEC	JNK2 →	+0.180	+2.469	.015	.010	3	2
UCEC	MEK1 →	+0.410	+2.169	.002	.003	3	2
UCEC	Rictor_pT1135 →	-0.098	-2.222	.010	.010	3	2
UCEC	C-Raf →	+0.193	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

EGFR_pY1068 by RAB6B expression — UCEC

Explore this box plot interactively →