RAB6B

Across TCGA pan-cancer cohorts, RAB6B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated RAB6B data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RAB6B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB6B expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

KIRC, BLCA, and UCEC are the cancer types where RAB6B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.489	0.780	<.001	61	view →
BLCA	DFS	Median	All	0.264	0.433	<.001	56	view →
UCEC	DFS	Quartile	All	0.734	0.871	.001	54	view →
LGG	DFS	Median	All	0.504	0.297	<.001	50	view →
CESC	DFS	Median	II,III,IV	0.285	0.659	.001	42	view →
PAAD	OS	Median	All	0.700	0.521	.001	34	view →
LIHC	OS	Tertile	All	0.667	0.871	<.001	32	view →
BRCA	DFS	Tertile	IV	0.306	0.873	.002	32	view →
COAD	OS	Tertile	III,IV	0.728	0.887	.011	31	view →
STAD	DFS	Median	All	0.390	0.572	.009	25	view →
SKCM	OS	Median	IV	0.265	0.728	.005	21	view →
OV	DFS	Tertile	IV	0.596	0.316	.010	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

RAB6B–KIRC (DFS)

Open the KIRC breakdown →