RAB6B

Across TCGA cell cohorts, RAB6B mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAB6B-associated genes across cancer lineages are GSK1070916, ETP-45835, and Palbociclib. Each is linked with RAB6B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB6B-to-partner and partner-to-RAB6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK1070916 grouped by RAB6B-low versus RAB6B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB6B→partner) and Y-score (partner→RAB6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK1070916 →	+0.761	+2.655	.009	.044	3	1
LARGE_INTESTINE	ETP-45835 →	+0.253	+2.652	.036	.045	3	1
LARGE_INTESTINE	Palbociclib →	+0.501	+2.646	.041	.047	2	1
LARGE_INTESTINE	CP466722 →	+0.427	+2.652	.030	.045	2	1
LARGE_INTESTINE	150412 →	+0.457	+2.777	.005	.038	2	1
LARGE_INTESTINE	Quizartinib →	+0.574	+2.652	<.001	.045	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GSK1070916 by RAB6B expression — LARGE_INTESTINE

Explore this box plot interactively →