RAB5C

Across TCGA pan-cancer cohorts, RAB5C RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated RAB5C data layer compared with 5 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RAB5C RNA is associated with better overall survival. In most high-consensus cancer types, elevated RAB5C expression acts as an unfavorable survival marker, although some lineages such as COAD and SCLC show a favorable association.

COAD, MESO, and LIHC are the cancer types where RAB5C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.917	0.659	<.001	67	view →
MESO	OS	Median	All	0.297	0.471	.006	45	view →
LIHC	DFS	Median	All	0.469	0.610	<.001	42	view →
ACC	DFS	Tertile	All	0.232	0.628	.002	41	view →
SCLC	DFS	Quartile	All	0.816	0.490	.005	41	view →
UVM	DFS	Tertile	II,III,IV	0.322	0.629	.003	41	view →
SKCM	DFS	Quartile	All	0.523	0.789	.001	40	view →
KIRC	OS	Median	All	0.723	0.547	<.001	39	view →
KIRP	DFS	Tertile	IV	0.118	0.667	.010	37	view →
HNSC	OS	Tertile	All	0.622	0.832	.001	36	view →
BRCA	OS	Median	III,IV	0.938	0.864	.001	33	view →
KICH	OS	Median	II,III,IV	0.622	0.959	.003	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

RAB5C–COAD (OS)

Open the COAD breakdown →