RAB5C

Across TCGA pan-cancer cohorts, RAB5C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RAB5C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAB5C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB5C is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where RAB5C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB5C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.886	<.001	12	view →
KICH	Female	II,III,IV	−1.598	<.001	10	view →
LIHC	Female	II,III,IV	+1.001	<.001	9	view →
KIRC	Male	II,III,IV	−0.467	<.001	6	view →
BRCA	All	All	+0.312	<.001	6	view →
CHOL	All	All	+1.570	<.001	5	view →
STAD	All	II,III,IV	+0.446	.001	4	view →
THCA	Male	II,III,IV	−0.275	.003	4	view →
ESCA	All	All	+0.972	.003	3	view →
UCEC	All	All	−0.556	.016	2	view →
KIRP	Female	II,III,IV	+0.323	.009	2	view →
BLCA	All	All	+0.303	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RAB5C–HNSC

Open the HNSC breakdown →