RAB5C

Across TCGA pan-cancer cohorts, RAB5C Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RAB5C data layer compared with 28 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher RAB5C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RAB5C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, BLCA, and CESC are the cancer types where RAB5C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	OS	Median	All	0.164	0.722	<.001	36	view →
CESC	OS	Median	II,III,IV	0.132	0.829	<.001	12	view →
PRAD	DFS	Median	All	0.065	0.774	<.001	6	view →
UCEC	DFS	Median	II,III,IV	1.000	0.445	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RAB5C–THYM (OS)

Open the THYM breakdown →