RAB5C

Across TCGA pan-cancer cohorts, RAB5C mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RAB5C data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher RAB5C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RAB5C expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

GBM, UCEC, and PDAC are the cancer types where RAB5C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.429	0.654	.009	11	view →
UCEC	DFS	Tertile	All	0.729	0.942	.004	10	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	8	view →
LUAD	OS	Tertile	II,III,IV	0.482	1.000	.026	7	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
CCRCC	DFS	Tertile	All	1.000	0.905	.023	5	view →
HNSC	DFS	Tertile	All	0.910	1.000	.018	4	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RAB5C–GBM (OS)

Open the GBM breakdown →