RAB5C

Across TCGA pan-cancer cohorts, RAB5C mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RAB5C’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RAB5C mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAB5C is over-expressed in tumor, although a few such as LUAD and CCRCC show the opposite, repressed pattern.

LUAD, PDAC, and CCRCC are the cancer types where RAB5C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB5C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.250	<.001	9	view →
PDAC	All	All	+0.505	<.001	7	view →
CCRCC	Male	All	−0.191	<.001	7	view →
COAD	Female	II,III,IV	+0.128	.015	5	view →
LSCC	All	All	−0.107	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RAB5C–LUAD

Open the LUAD breakdown →