RAB5A

Across TCGA pan-cancer cohorts, RAB5A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RAB5A data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher RAB5A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB5A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, LUAD, and UCEC are the cancer types where RAB5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	36	view →
LUAD	OS	Median	All	0.258	0.787	.018	6	view →
UCEC	DFS	Median	II,III,IV	1.000	0.489	.044	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RAB5A–CESC (DFS)

Open the CESC breakdown →