RAB5A

Across TCGA pan-cancer cohorts, RAB5A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RAB5A’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RAB5A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB5A is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

LIHC, KIRC, and THCA are the cancer types where RAB5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	+0.544	<.001	8	view →
KIRC	Male	II,III,IV	−0.432	<.001	7	view →
THCA	All	All	−0.275	.002	6	view →
KICH	All	All	−0.580	.001	5	view →
LUSC	All	All	−0.287	<.001	5	view →
BLCA	Male	IV	+0.467	.009	4	view →
BRCA	All	II,III,IV	+0.209	.001	4	view →
CHOL	All	All	+0.654	.031	2	view →
HNSC	All	II,III,IV	−0.232	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RAB5A–LIHC

Open the LIHC breakdown →