RAB5A

Across TCGA pan-cancer cohorts, RAB5A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RAB5A data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RAB5A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RAB5A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where RAB5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.946	0.679	.002	13	view →
LSCC	DFS	Tertile	All	0.296	0.823	.007	4	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →
PDAC	OS	Median	III,IV	0.652	0.856	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RAB5A–HNSC (DFS)

Open the HNSC breakdown →