RAB5A

Across TCGA patient cohorts, RAB5A mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB5A-associated genes across cancer lineages are ATM, 4E-BP1, and eIF4E. Each is linked with RAB5A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB5A-to-partner and partner-to-RAB5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RAB5A-low versus RAB5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB5A→partner) and Y-score (partner→RAB5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.386	-2.169	.023	.003	3	2
UCEC	4E-BP1 →	+0.262	+2.029	.010	.017	3	2
UCEC	eIF4E →	+0.183	+2.335	.020	.018	3	1
UCEC	A-Raf_pS299 →	-0.129	-2.222	.004	.010	3	1
UCEC	JNK2 →	+0.229	+1.765	.002	.014	3	1
UCEC	MEK1 →	+0.422	+3.000	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATM by RAB5A expression — UCEC

Explore this box plot interactively →