RAB5A

Across TCGA cell cohorts, RAB5A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,637 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RAB5A-associated GO terms across cancer lineages are Amyloid-beta clearance by transcytosis, Protein localization to early endosome, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with RAB5A in more than 16 cancer types. Because this analysis shows association rather than direction, both RAB5A-to-partner and partner-to-RAB5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amyloid-beta clearance by transcytosis grouped by RAB5A-low versus RAB5A-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB5A→partner) and Y-score (partner→RAB5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Amyloid-beta clearance by transcytosis →	+0.199	+1.134	<.001	<.001	3	17
BONE	Protein localization to early endosome →	+0.256	+0.710	<.001	<.001	3	17
OVARY	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.077	+0.865	<.001	<.001	3	14
SOFT_TISSUE	Regulation of protein exit from endoplasmic reticulum →	+0.129	+0.945	<.001	<.001	3	13
BONE	COPII-coated vesicle cargo loading →	+0.108	+0.730	<.001	<.001	3	13
BLOOD_Myeloma	COPII-coated vesicle budding →	+0.100	+0.765	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,637 associations by consensus.

Amyloid-beta clearance by transcytosis by RAB5A expression — URINARY_TRACT

Explore this box plot interactively →