RAB5A

Across TCGA cell cohorts, RAB5A mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAB5A-associated genes across cancer lineages are OR2T8, FAM153B, and USP17L7. Each is linked with RAB5A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB5A-to-partner and partner-to-RAB5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T8 grouped by RAB5A-low versus RAB5A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB5A→partner) and Y-score (partner→RAB5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2T8 →	+0.165	+3.584	<.001	.004	3	1
LARGE_INTESTINE	FAM153B →	+0.538	+3.618	<.001	.003	3	1
LARGE_INTESTINE	USP17L7 →	+0.061	+3.333	<.001	.009	3	1
BLOOD_Lymphoma	RBMY1F →	+0.034	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	OLIG3 →	+1.428	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	SYCP1 →	+0.026	+4.350	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR2T8 by RAB5A expression — LARGE_INTESTINE

Explore this box plot interactively →