RAB4B

Across TCGA patient cohorts, RAB4B mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB4B-associated genes across cancer lineages are GMP, lymphatic Endothelial cells, and MEP. Each is linked with RAB4B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB4B-to-partner and partner-to-RAB4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by RAB4B-low versus RAB4B-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB4B→partner) and Y-score (partner→RAB4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	GMP →	+0.136	+3.760	<.001	.019	3	1
UCEC	lymphatic Endothelial cells →	-0.022	-3.129	.038	.019	3	1
UCEC	MEP →	+0.043	+3.084	<.001	.016	3	1
UCEC	pDC →	+0.064	+3.491	.003	.002	3	1
UCEC	Mesangial cells →	-0.047	-3.153	.006	.019	2	1
UCEC	Th2 cells →	+0.294	+3.329	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GMP by RAB4B expression — ESCA

Explore this box plot interactively →