RAB40A

Across TCGA patient cohorts, RAB40A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB40A-associated genes across cancer lineages are eEF2, EGFR_pY1068, and FOXO3a_pS318_S321. Each is linked with RAB40A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB40A-to-partner and partner-to-RAB40A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RAB40A-low versus RAB40A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB40A→partner) and Y-score (partner→RAB40A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.485	+2.584	<.001	.010	3	1
UCEC	EGFR_pY1068 →	-0.305	-3.087	.002	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.171	-2.896	<.001	.001	3	1
UCEC	ACC1 →	+0.368	+3.472	.011	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-2.222	.008	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.425	-2.459	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by RAB40A expression — UCEC

Explore this box plot interactively →