RAB3IP

Across TCGA pan-cancer cohorts, RAB3IP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RAB3IP data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RAB3IP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RAB3IP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where RAB3IP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.858	0.529	<.001	67	view →
LUAD	OS	Median	III,IV	0.285	0.879	.001	28	view →
GBM	OS	Median	All	0.645	0.879	.029	2	view →
HNSC	DFS	Tertile	III,IV	0.927	0.685	.037	2	view →
PDAC	DFS	Tertile	All	0.486	0.320	.028	2	view →
LSCC	DFS	Median	All	0.966	0.904	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RAB3IP–CCRCC (DFS)

Open the CCRCC breakdown →