RAB3IP

Across TCGA patient cohorts, RAB3IP mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB3IP-associated genes across cancer lineages are MEK1, MSH6, and TIGAR. Each is linked with RAB3IP in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB3IP-to-partner and partner-to-RAB3IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RAB3IP-low versus RAB3IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB3IP→partner) and Y-score (partner→RAB3IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.297	+1.700	.043	.042	3	2
UCEC	MSH6 →	-0.419	-2.321	.001	.033	3	2
UCEC	TIGAR →	+0.149	+1.512	.014	.035	3	2
UCEC	EGFR →	-0.206	-1.906	.001	.016	3	1
UCEC	Ku80 →	+0.214	+1.884	.024	.030	3	1
UCEC	p62 Lck ligand →	+0.332	+2.469	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MEK1 by RAB3IP expression — UCEC

Explore this box plot interactively →