RAB3C

Across TCGA patient cohorts, RAB3C mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB3C-associated genes across cancer lineages are GSK-3a-b_pS21_S9, MEK1, and MSH2. Each is linked with RAB3C in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB3C-to-partner and partner-to-RAB3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by RAB3C-low versus RAB3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB3C→partner) and Y-score (partner→RAB3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.430	+1.884	.030	.030	3	1
UCEC	MEK1 →	+0.408	+3.459	.016	.005	3	1
UCEC	MSH2 →	-0.303	-3.143	.004	.018	3	1
UCEC	S6_pS240_S244 →	+0.729	+3.321	<.001	.010	3	1
UCEC	Caspase-8 →	-0.286	-3.432	.014	.005	3	1
UCEC	eIF4G →	+0.334	+2.584	.021	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GSK-3a-b_pS21_S9 by RAB3C expression — UCEC

Explore this box plot interactively →