RAB3C

Across TCGA pan-cancer cohorts, RAB3C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RAB3C’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RAB3C RNA is repressed in tumor relative to normal tissue. In most cancer types RAB3C is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, KIRC, and BRCA are the cancer types where RAB3C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB3C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.593	<.001	11	view →
KIRC	Male	All	+0.562	<.001	7	view →
BRCA	All	III,IV	−0.852	<.001	6	view →
UCEC	All	All	−0.512	.004	6	view →
BLCA	All	IV	−0.480	.017	5	view →
LUSC	Male	II,III,IV	−0.338	<.001	4	view →
HNSC	Male	All	−0.189	.011	4	view →
STAD	All	IV	−0.486	.019	3	view →
READ	Female	All	−1.090	<.001	2	view →
LIHC	All	All	+0.362	.008	2	view →
KIRP	Male	All	−0.114	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RAB3C–COAD

Open the COAD breakdown →