RAB3B

Across TCGA patient cohorts, RAB3B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB3B-associated genes across cancer lineages are A-Raf_pS299, ERK2, and Fibronectin. Each is linked with RAB3B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB3B-to-partner and partner-to-RAB3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RAB3B-low versus RAB3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB3B→partner) and Y-score (partner→RAB3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.143	-3.321	.007	.009	3	1
UCEC	ERK2 →	+0.279	+3.321	.001	.010	3	1
UCEC	Fibronectin →	-0.337	-3.160	.023	.019	3	1
UCEC	Gab2 →	+0.409	+2.999	.010	.035	3	1
UCEC	ACVRL1 →	-0.170	-2.000	.005	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.215	-3.321	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

A-Raf_pS299 by RAB3B expression — UCEC

Explore this box plot interactively →