RAB3B

Across TCGA pan-cancer cohorts, RAB3B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RAB3B data layer compared with 1 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RAB3B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RAB3B expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

KIRC, MESO, and STAD are the cancer types where RAB3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.542	0.698	<.001	121	view →
MESO	OS	Median	All	0.258	0.518	<.001	111	view →
STAD	DFS	Tertile	II,III,IV	0.535	0.723	<.001	84	view →
UVM	DFS	Median	All	0.421	0.745	<.001	57	view →
CESC	OS	Median	All	0.729	0.860	.003	34	view →
ACC	DFS	Tertile	All	0.289	0.822	<.001	33	view →
LUAD	OS	Tertile	All	0.391	0.623	.001	32	view →
SCLC	DFS	Quartile	II,III,IV	0.817	0.385	.003	27	view →
ESCA	DFS	Tertile	III,IV	0.304	0.582	.006	24	view →
BRCA	OS	Tertile	IV	0.892	0.325	.007	24	view →
HNSC	OS	Quartile	All	0.558	0.820	.001	23	view →
SARC	OS	Median	All	0.434	0.581	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RAB3B–KIRC (OS)

Open the KIRC breakdown →