RAB39B

Across TCGA pan-cancer cohorts, RAB39B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RAB39B data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RAB39B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RAB39B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where RAB39B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.456	0.288	<.001	132	view →
UCEC	DFS	Median	All	0.555	0.727	<.001	88	view →
LUAD	DFS	Median	All	0.427	0.246	<.001	71	view →
PAAD	DFS	Median	All	0.386	0.194	<.001	67	view →
SKCM	OS	Median	All	0.844	0.719	<.001	55	view →
SCLC	OS	Tertile	II,III,IV	0.797	0.365	.001	47	view →
BRCA	OS	Median	III,IV	0.944	0.858	.003	29	view →
KIRC	DFS	Quartile	II,III,IV	0.749	0.563	.008	29	view →
DLBC	OS	Median	All	0.751	1.000	.007	20	view →
ACC	DFS	Median	II,III,IV	0.566	0.853	.012	16	view →
UVM	OS	Tertile	All	0.954	0.688	.012	16	view →
CESC	OS	Tertile	All	0.848	0.705	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RAB39B–HNSC (DFS)

Open the HNSC breakdown →