RAB39B

Across TCGA pan-cancer cohorts, RAB39B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RAB39B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RAB39B RNA is repressed in tumor relative to normal tissue. In most cancer types RAB39B is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and KIRC are the cancer types where RAB39B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB39B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.714	<.001	11	view →
KIRP	Female	II,III,IV	−0.871	<.001	9	view →
KIRC	Male	All	−0.330	<.001	6	view →
KICH	Male	III,IV	−0.900	.007	4	view →
BRCA	All	II,III,IV	+0.512	<.001	4	view →
LUAD	Female	II,III,IV	−0.516	.008	3	view →
LUSC	All	III,IV	−0.795	.010	2	view →
PRAD	All	All	+0.648	<.001	2	view →
READ	All	All	−0.517	.015	2	view →
THCA	Male	III,IV	−0.804	.049	1	view →
HNSC	All	III,IV	+0.273	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RAB39B–COAD

Open the COAD breakdown →