RAB39A

Across TCGA patient cohorts, RAB39A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB39A-associated genes across cancer lineages are 14-3-3_beta, Rad50, and S6_pS240_S244. Each is linked with RAB39A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB39A-to-partner and partner-to-RAB39A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RAB39A-low versus RAB39A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB39A→partner) and Y-score (partner→RAB39A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.112	-3.893	.010	<.001	3	1
UCEC	Rad50 →	-0.212	-3.156	.045	.018	3	1
UCEC	S6_pS240_S244 →	+0.426	+3.000	.016	.036	3	1
UCEC	TIGAR →	+0.196	+3.321	.003	.010	3	1
UCEC	Tuberin →	+0.236	+2.469	.045	.010	3	1
UCEC	VHL →	-0.831	-2.584	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

14-3-3_beta by RAB39A expression — UCEC

Explore this box plot interactively →