RAB39A

Across TCGA pan-cancer cohorts, RAB39A RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RAB39A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAB39A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB39A is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where RAB39A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB39A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.533	<.001	12	view →
KIRC	Male	IV	+1.111	<.001	11	view →
KIRP	All	II,III,IV	+0.967	<.001	11	view →
BRCA	Female	All	+0.266	<.001	4	view →
STAD	All	II,III,IV	+0.471	.038	2	view →
LUAD	All	All	+0.339	.015	2	view →
READ	Female	All	−0.532	.019	1	view →
CHOL	All	All	+0.263	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RAB39A–HNSC

Open the HNSC breakdown →