RAB37

Across TCGA patient cohorts, RAB37 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB37-associated genes across cancer lineages are Notch1, Shc_pY317, and Tuberin_pT1462. Each is linked with RAB37 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB37-to-partner and partner-to-RAB37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RAB37-low versus RAB37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB37→partner) and Y-score (partner→RAB37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.151	+3.183	.011	.009	3	2
UCEC	Shc_pY317 →	-0.162	-2.459	.011	.019	3	2
UCEC	Tuberin_pT1462 →	+0.203	+2.222	.038	.011	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.700	.040	.044	3	1
UCEC	A-Raf_pS299 →	-0.121	-2.222	.017	.011	3	1
UCEC	FoxM1 →	+0.239	+1.700	.029	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Notch1 by RAB37 expression — UCEC

Explore this box plot interactively →